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No differences were observed in plasma NfL or GFAP across ages 18 to 30 between variant carriers and non-carriers of C9orf72, GRN, or MAPT .

Journal: medRxiv

Article Title: Trajectories of brain structure and function in young adult carriers of genetic frontotemporal dementia variants

doi: 10.64898/2026.06.08.26355165

Figure Lengend Snippet: No differences were observed in plasma NfL or GFAP across ages 18 to 30 between variant carriers and non-carriers of C9orf72, GRN, or MAPT .

Article Snippet: In ALLFTD, plasma NfL concentrations were measured using the Simoa NF-Light digital immunoassay (Quanterix, Cat. No. 103186), and plasma GFAP using the Simoa GFAP digital immunoassay (Quanterix, Cat. No. 102336, Lot 503909), both on the HD-X Analyzer.

Techniques: Clinical Proteomics, Variant Assay